4-Cresol dehydrogenase (hydroxylating)

In enzymology, a 4-cresol dehydrogenase (hydroxylating) (EC 1.17.99.1) is an enzyme that catalyzes the chemical reaction

4-cresol + acceptor + H₂O ${\displaystyle \rightleftharpoons }$ 4-hydroxybenzaldehyde + reduced acceptor

4-cresol dehydrogenase (hydroxylating)
Identifiers
EC no.	1.17.99.1
CAS no.	66772-07-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are 4-cresol, acceptor, and H₂O, whereas its two products are 4-hydroxybenzaldehyde and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH₂ groups with other acceptors. The systematic name of this enzyme class is 4-cresol:acceptor oxidoreductase (methyl-hydroxylating). Other names in common use include p-cresol–(acceptor) oxidoreductase (hydroxylating), and p-cresol methylhydroxylase. This enzyme participates in toluene and xylene degradation. It has 2 cofactors: FAD, and Cytochrome c.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1DII, 1DIQ, 1WVE, and 1WVF.