4-hydroxybenzoate polyprenyltransferase

In enzymology, a 4-hydroxybenzoate polyprenyltransferase (EC 2.5.1.39) is an enzyme that catalyzes the chemical reaction

a polyprenyl diphosphate + 4-hydroxybenzoate ${\displaystyle \rightleftharpoons }$ diphosphate + a 4-hydroxy-3-polyprenylbenzoate

4-hydroxybenzoate polyprenyltransferase
Identifiers
EC no.	2.5.1.39
CAS no.	9030-77-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are a polyprenyl diphosphate and 4-hydroxybenzoate, whereas its two products are diphosphate and 4-hydroxy-3-polyprenylbenzoate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. This enzyme participates in ubiquinone biosynthesis.^[1]

Nomenclature

The systematic name of this enzyme class is polyprenyl-diphosphate:4-hydroxybenzoate polyprenyltransferase. Other names in common use include:

• nonaprenyl-4-hydroxybenzoate transferase,
• 4-hydroxybenzoate transferase,
• p-hydroxybenzoate dimethylallyltransferase,
• p-hydroxybenzoate polyprenyltransferase,
• p-hydroxybenzoic acid-polyprenyl transferase,
• p-hydroxybenzoic-polyprenyl transferase, and
• 4-hydroxybenzoate nonaprenyltransferase