5-phytase

The enzyme 5-phytase^[1] (EC 3.1.3.72) catalyzes the reaction

myo-inositol hexakisphosphate + H₂O = 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate

Identifiers
EC no.	3.1.3.72
CAS no.	357208-41-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

myo-Inositol hexakisphosphate is also known as phytic acid.

These enzymes belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-hexakisphosphate 5-phosphohydrolase.

Prevalence

Of the hundreds of phytase enzymes that have been characterized in the literature, only two have been characterized as 5-phytases.^{[2][needs update]} A histidine acid phosphatases purified from lily pollen^[1] and a protein tyrosine phosphatase-like phytase from Selenomonas ruminantium subsp. lactilytica^[2] were both found to have specificity for the 5-phosphate position of myo-inositol hexakisphosphate.

Structural studies

As of late 2007, only the phytase purified from lily pollen had its structure solved, with PDB accession codes 1U24, 1U25, 1U26, 2B4O, 2B4P, and 2B4U.

See also

• 3-phytase (1-phytase)
• 4-phytase (6-phytase)
• Protein tyrosine phosphatase