5-MeO-T-NBOMe

5-MeO-T-NBOMe, also known as 5MT-NBOMe or NBOMe-5-MeO-T, is a psychedelic of the tryptamine family related to the 25-NB (NBOMe) drugs.^[1][2] It has been sold online as a designer drug.^[1][2]

5-MeO-T-NBOMe

Clinical data
Other names	5MT-NBOMe; NBOMe-5-MeO-T
Drug class	Serotonin 5-HT2 receptor agonist; Serotonergic psychedelic; Hallucinogen
Identifiers
IUPAC name 2-(5-methoxy-1H-indol-3-yl)-N-[(2-methoxyphenyl)methyl]ethanamine
CAS Number	1335331-37-7
PubChem CID	122363719
ChemSpider	26599679
Chemical and physical data
Formula	C19H22N2O2
Molar mass	310.397 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=CC2=C(C=C1)NC=C2CCNCC3=CC=CC=C3OC
InChI InChI=1S/C19H22N2O2/c1-22-16-7-8-18-17(11-16)14(13-21-18)9-10-20-12-15-5-3-4-6-19(15)23-2/h3-8,11,13,20-21H,9-10,12H2,1-2H3 Key:OROYLKZKNDLGIQ-UHFFFAOYSA-N

Pharmacology

5-MeO-T-NBOMe is a serotonin 5-HT₂ receptor agonist and produces the head-twitch response in rodents.^[1] However, compared to 25I-NBOMe, the drug is much less potent in producing the head-twitch response (~10-fold) and produces a much weaker maximal response (~25%).^[1] 5-MeO-T-NBOMe is many times less potent than comparable phenethylamines such as 25C-NBOMe, but is still a reasonably potent and effective partial agonist for the 5-HT₂ family of serotonin receptors.^[1][2] A number of related compounds have also been developed, and in contrast to the phenethylamine counterparts the meta-substituted benzyl derivatives are in many cases more potent than the ortho-substituted benzyl compounds.^[3]

History

5-MeO-T-NBOMe was described by David E. Nichols and colleagues in 2015.^[1]

See also

• Substituted tryptamine
• N-Benzyltryptamine
• 4-HO-NALT
• 5-MeO-NBpBrT
• 5-MeO-DALT
• 5-MeO-DiPT
• Pertine