Pertine

The pertines, also known as phenylpiperazinylethylindoles, are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs:^[1][2]

• Alpertine (WIN-31665)
• Milipertine (WIN-18935)
• Oxypertine (WIN-18501)
• Solypertine (WIN-18413)

Chemical structure of oxypertine, the most well-known drug of the pertine group.

Oxypertine is known to show high affinity for the serotonin 5-HT₂ and dopamine D₂ receptors (K_i = 8.6 nM and 30 nM, respectively) and to also act as a catecholamine depleting agent.^[2][3] Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals.^[2][4]

Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety.^[1][2]

The pertines were developed and initially described in the 1960s and 1970s.^[1]

Chemical structures of pertines

• 
  Alpertine
• 
  Milipertine
• 
  Oxypertine
• 
  Solypertine

See also

• Cyclized tryptamine
• 5-MeO-T-NBOMe
• N-Benzyltryptamine
• Carmoxirole