6-Fluoro-AMT

6-Fluoro-α-methyltryptamine (6-fluoro-AMT, 6F-AMT) is a tryptamine derivative related to compounds such as α-methyltryptamine (AMT) and 5-MeO-AMT which has been sold as a designer drug.^[1][2]

6-Fluoro-AMT

Clinical data
Other names	6-Fluoro-AMT; 6-Fluoro-αMT; 6F-AMT; 6F-αMT; 6-F-AMT; 6-F-αMT
Identifiers
IUPAC name 1-(6-fluoro-1H-indol-3-yl)propan-2-amine
CAS Number	712-11-8 Y
PubChem CID	15289992
ChemSpider	14228507
UNII	46F5HN29NW
CompTox Dashboard (EPA)	DTXSID701045426
Chemical and physical data
Formula	C11H13FN2
Molar mass	192.237 g·mol−1
3D model (JSmol)	Interactive image
SMILES NC(C)CC1=CNC2=CC(F)=CC=C21
InChI InChI=1S/C11H13FN2/c1-7(13)4-8-6-14-11-5-9(12)2-3-10(8)11/h2-3,5-7,14H,4,13H2,1H3 Key:XYJYWUUXCUJXAI-UHFFFAOYSA-N

Animal tests showed the drug to be somewhat less potent in terms of pharmacological activity than AMT or 5-fluoro-AMT.^[3] It produces the head-twitch response, a behavioral proxy of psychedelic-like effects, in rodents.^[4][5][6] Its IC₅₀Tooltip half-maximal inhibitory concentration for monoamine oxidase A (MAO-A) inhibition is 580 to 1,800 nM, compared to 180 to 450 nM for 5-fluoro-AMT and 380 nM for AMT.^[5][7][8]

6-Fluoro-AMT was allegedly manufactured and sold from the laboratory operated by Leonard Pickard and Gordon Todd Skinner, who described 6-fluoro-AMT as "a beast".^[1] In interviews, Skinner stated that he first began to experiment with 6-fluoro-AMT in the early 1980s by giving it to high school friends.^[2] Their experiences made him cautious about the appropriate doses, which he said ranged from 25 to 75 mg (Skinner weighed about 250 lbs at the time of his own bioassay).^[2] Skinner said that 6-fluoro-AMT is a long-lasting psychedelic with more time distortion and that it was enhanced by combination with ALD-52.^[2]

6-Fluoro-AMT was first described in the scientific literature, by Asher Kalir and Stephen Szara, by at least 1963.^[3]

See also

• Substituted α-alkyltryptamine
• 5-Fluoro-AET
• 5-Fluoro-AMT
• 6-Fluoro-DMT
• 6-Fluoro-DET
• 7-Chloro-AMT
• O-4310