PRO-LAD

PRO-LAD, also known as 6-propyl-6-nor-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).^[1][3]

PRO-LAD

Clinical data
Other names	6-Propyl-6-nor-LSD; 6-Propyl-6-norlysergic acid diethylamide; N,N-Diethyl-6-propyl-9,10-didehydroergoline-8β-carboxamide
Routes of administration	Oral[1]
Drug class	Serotonin receptor modulator; Serotonergic psychedelic; Hallucinogen
Legal status
Legal status	DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act US: Analogue to a Schedule I/II drug but only if it is intended for human consumption Illegal in France[2]
Identifiers
IUPAC name (6aR,9R)-N,N-diethyl-7-propyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
CAS Number	65527-63-1 Y
PubChem CID	44457803
ChemSpider	21106361 Y
UNII	RVR83W9XMC
ChEMBL	ChEMBL22258 Y
CompTox Dashboard (EPA)	DTXSID50215824
Chemical and physical data
Formula	C22H29N3O
Molar mass	351.494 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(CC)C(=O)[C@@H]2C=C1c3cccc4[nH]cc(C[C@H]1N(C2)CCC)c34
InChI InChI=1S/C22H29N3O/c1-4-10-25-14-16(22(26)24(5-2)6-3)11-18-17-8-7-9-19-21(17)15(13-23-19)12-20(18)25/h7-9,11,13,16,20,23H,4-6,10,12,14H2,1-3H3/t16-,20-/m1/s1 Y Key:HZKYLVLOBYNKKM-OXQOHEQNSA-N Y
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Use and effects

PRO-LAD was described by Alexander Shulgin in his book TiHKAL.^[1] It is a psychedelic similar to LSD, and has around the same potency as LSD itself, with an active dose reported at between 100 and 200 μg.^[1][4]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

Pharmacodynamics

PRO-LAD is slightly more potent in substituting for LSD in rodent drug discrimination tests than LSD itself.^[3]

Society and culture

Legal status

Switzerland

PRO-LAD is illegal in Switzerland as of December 2015.^[5]

United Kingdom

On June 10, 2014, the United Kingdom Advisory Council on the Misuse of Drugs (ACMD) recommended that PRO-LAD be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use.^[6] The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.

See also

• Substituted lysergamide
• ETH-LAD
• AL-LAD
• FLUORETH-LAD