6-hydroxyhexanoate dehydrogenase

In enzymology, 6-hydroxyhexanoate dehydrogenase (EC 1.1.1.258) is an enzyme that catalyzes the chemical reaction

6-hydroxyhexanoic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

6-oxohexanoic acid

+ NADH

 

6-hydroxyhexanoate dehydrogenase
Identifiers
EC no.	1.1.1.258
CAS no.	77000-03-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are 6-hydroxyhexanoic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 6-oxohexanoic acid, reduced NADH, and a proton.^[1][2][3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 6-hydroxyhexanoate:NAD⁺ oxidoreductase. This enzyme participates in caprolactam degradation.