7-Chlorotryptamine

7-Chlorotryptamine (7-chloro-T, 7-CT, or 7-Cl-T; code name PAL-532) is a serotonin receptor agonist and monoamine releasing agent (MRA) of the tryptamine family.^[1] It is a pale yellow solid.^[2] It is a full agonist of the serotonin 5-HT_2A receptor, with an EC₅₀Tooltip half-maximal effective concentration of 18.8 nM and an E_maxTooltip maximal efficacy of 102%.^[1] In addition, it is a serotonin releasing agent (SRA), with EC₅₀ values of 8.03 nM for serotonin, 656 nM for norepinephrine, and 1,330 nM for dopamine in rat brain synaptosomes.^[1] The drug is one of the most potent SRAs in vitro known, after 6-fluorotryptamine (6-FT) and naphthylaminopropane (NAP; PAL-287).^[1] 7-CT was first described in the scientific literature by 2014.^[1]

7-Chlorotryptamine

Clinical data
Other names	7-Chloro-T; 7-CT; 7-Cl-T; PAL-532; PAL532
Drug class	Serotonin receptor agonist; Serotonin releasing agent
Identifiers
IUPAC name 2-(7-chloro-1H-indol-3-yl)ethanamine
CAS Number	3804-16-8
PubChem CID	145709
ChemSpider	128536
ChEMBL	ChEMBL3330643
CompTox Dashboard (EPA)	DTXSID50191457
Chemical and physical data
Formula	C10H11ClN2
Molar mass	194.66 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC2=C(C(=C1)Cl)NC=C2CCN
InChI InChI=1S/C10H11ClN2/c11-9-3-1-2-8-7(4-5-12)6-13-10(8)9/h1-3,6,13H,4-5,12H2 Key:QKRNGBURTLCWBQ-UHFFFAOYSA-N

See also

• 7-Chloro-AMT
• 7-Methyl-DMT
• 5-Fluorotryptamine
• 6-Fluorotryptamine
• 1-Methyltryptamine
• 5-Methyltryptamine
• 5-Methoxytryptamine