8,11-Dihydroxytetrahydrocannabinol

8,11-Dihydroxytetrahydrocannabinol (8β,11-diOH-Δ⁹-THC) is an active metabolite of THC, the main active component of cannabis. The 8β enantiomer retains psychoactive effects in animal studies with only slightly lower potency than THC, while the 8α enantiomer is much weaker. Both enantiomers have a shorter half-life in the body than 11-hydroxy-THC, making 8,11-dihydroxy-THC potentially useful for drug testing to distinguish between recent cannabis use and use longer in the past.^[1][2][3]

8,11-Dihydroxytetrahydrocannabinol

Identifiers
IUPAC name (6aR,8R,10aR)-9-(Hydroxymethyl)-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-1,8-diol
CAS Number	36913-21-0 N[EPA]
PubChem CID	101993955
ChemSpider	130500
CompTox Dashboard (EPA)	DTXSID80190397
Chemical and physical data
Formula	C21H30O4
Molar mass	346.467 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCc1cc2OC(C)(C)[C@@H]3C[C@@H](O)C(=C[C@H]3c2c(O)c1)CO
InChI InChI=1S/C21H30O4/c1-4-5-6-7-13-8-18(24)20-15-10-14(12-22)17(23)11-16(15)21(2,3)25-19(20)9-13/h8-10,15-17,22-24H,4-7,11-12H2,1-3H3/t15-,16-,17-/m1/s1 Key:XTDYIISRNODHHT-BRWVUGGUSA-N

See also

• 3'-Hydroxy-THC
• 7-Hydroxycannabidiol
• 11-Hydroxy-Delta-8-THC
• 11-Nor-9-carboxy-THC
• Cannabitriol
• Cannabiripsol