A-366,833

A-366,833 is a drug developed by Abbott, which acts as an agonist at neural nicotinic acetylcholine receptors selective for the α4β2 subtype, and has been researched for use as an analgesic, although it has not passed clinical trials.^[2] Its structure has a nicotinonitrile (3-cyanopyridine) core bound through C5 to the N6 of (1R,5S)-3,6-diazabicyclo[3.2.0]heptane.^[3]

A-366,833

Identifiers
IUPAC name 5-[(1R,5S)-3,6-Diazabicyclo[3.2.0]hept-6-yl]pyridine-3-carbonitrile
CAS Number	370882-41-0 Y
PubChem CID	9834234
ChemSpider	8009955 Y
UNII	6XRK9HTJ6M
ChEMBL	ChEMBL239931 Y
Chemical and physical data
Formula	C11H12N4
Molar mass	200.245 g·mol−1
3D model (JSmol)	Interactive image
Melting point	101.4–102.9 °C (214.5–217.2 °F) [1]
SMILES N#CC1=CN=CC(N2[C@]3([H])CNC[C@]3([H])C2)=C1
InChI InChI=1S/C11H12N4/c12-2-8-1-10(5-13-3-8)15-7-9-4-14-6-11(9)15/h1,3,5,9,11,14H,4,6-7H2/t9-,11-/m1/s1 N Key:GPXAWLDGWSBLKM-MWLCHTKSSA-N N
NY (what is this?)  (verify)