ADAMTS14

ADAMTS14 encodes a member of the ADAMTS protein family. Family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The proteolytic process of the encoded preproprotein generates a mature enzyme. The enzyme cleaves the amino-propeptides of fibrillar collagens, enabling collagen fibril formation before the assembly of collagen, a major extracellular matrix (ECM) protein.^[1][2]