Adiponectin receptor 1

Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene.^[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1.^[6]

ADIPOR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WXV
Identifiers
Aliases	ADIPOR1, adiponectin receptor 1, ACDCR1, CGI45, PAQR1, TESBP1A, CGI-45
External IDs	OMIM: 607945; MGI: 1919924; HomoloGene: 69199; GeneCards: ADIPOR1; OMA:ADIPOR1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 202,940,826 bp[1] End 202,958,572 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 134,343,116 bp[2] End 134,361,089 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte skin of leg bone marrow skin of abdomen islet of Langerhans olfactory zone of nasal mucosa right lung minor salivary glands upper lobe of left lung Top expressed in blood granulocyte stroma of bone marrow knee joint fetal liver hematopoietic progenitor cell neural layer of retina triceps brachii muscle atrium medial head of gastrocnemius muscle ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function adipokinetic hormone receptor activity adiponectin binding metal ion binding identical protein binding protein heterodimerization activity protein kinase binding signaling receptor activity Cellular component integral component of membrane membrane intrinsic component of plasma membrane plasma membrane Biological process glucose homeostasis lipid metabolism leptin-mediated signaling pathway adiponectin-activated signaling pathway fatty acid metabolic process regulation of lipid metabolic process regulation of glucose metabolic process negative regulation of cell growth fatty acid oxidation hormone-mediated signaling pathway positive regulation of insulin receptor signaling pathway positive regulation of receptor signaling pathway via JAK-STAT negative regulation of epithelial to mesenchymal transition negative regulation of receptor signaling pathway via JAK-STAT negative regulation of epithelial cell migration negative regulation of NIK/NF-kappaB signaling G protein-coupled receptor signaling pathway regulation of fatty acid biosynthetic process positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51094 72674 Ensembl ENSG00000159346 ENSMUSG00000026457 UniProt Q96A54 Q91VH1 RefSeq (mRNA) NM_001290553 NM_001290557 NM_001290629 NM_015999 NM_028320 NM_001306069 RefSeq (protein) NP_001277482 NP_001277486 NP_001277558 NP_057083 NP_001292998 NP_082596 Location (UCSC) Chr 1: 202.94 – 202.96 Mb Chr 1: 134.34 – 134.36 Mb PubMed search [3] [4]
Wikidata
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Structure

Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.^[5]

Function

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.^[5][7] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.^[8]

Ligands

Agonists

Peptide

• Adiponectin
• ADP-355^[9]
• ADP-399^[9]

Non-peptide

• AdipoRon^[10]
• (−)-Arctigenin^[11]
• Arctiin^[11]
• Gramine^[11]
• Matairesinol^[11]

Antagonists

Peptide

• ADP-400^[9]

See also

• Adiponectin receptor
• Adiponectin receptor 2