Adiponectin receptor 2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Adiponectin receptor 2

Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.[6]

Quick Facts ADIPOR2, Available structures ...
ADIPOR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADIPOR2, adiponectin receptor 2, ACDCR2, PAQR2
External IDsOMIM: 607946; MGI: 93830; HomoloGene: 56119; GeneCards: ADIPOR2; OMA:ADIPOR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024551
NM_001375363
NM_001375364
NM_001375365

NM_197985
NM_001355692

RefSeq (protein)

NP_078827
NP_001362292
NP_001362293
NP_001362294

NP_932102
NP_001342621

Location (UCSC)Chr 12: 1.69 – 1.79 MbChr 6: 119.33 – 119.39 Mb
PubMed search[3][4]
Wikidata
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Structure

Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[5]

Function

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[5] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.[7]

Ligands

Agonists

Peptide

Non-peptide

Antagonists

Peptide

See also

References

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