ADP-dependent NAD(P)H-hydrate dehydratase

ADP-dependent NAD(P)H-hydrate dehydratase (EC 4.2.1.136, (6S)-β-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing), (6S)-6-β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing, NADH-forming)) is an enzyme with systematic name (6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming).^[1] This enzyme catalyses the following chemical reaction

(1) ADP + (6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide ${\displaystyle \rightleftharpoons }$ AMP + phosphate + NADH

(2) ADP + (6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate ${\displaystyle \rightleftharpoons }$ AMP + phosphate + NADPH

ADP-dependent NAD(P)H-hydrate dehydratase
Identifiers
EC no.	4.2.1.136
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme acts equally well on hydrated NADH and hydrated NADPH.