ADX-71441

ADX-71441 is a GABA_B receptor positive allosteric modulator currently being investigated as a potential treatment for anxiety, epilepsy, pain and other conditions.

ADX71441

Names
IUPAC name N-[5-[4-[(4-chloro-3-fluorophenyl)methyl]-6-methoxy-3,5-dioxo-1,2,4-triazin-2-yl]-2-fluorophenyl]acetamide
Identifiers
CAS Number	1207440-88-7
3D model (JSmol)	Interactive image
PubChem CID	25106292
InChI Key: BQDMEJYNGXEHSW-UHFFFAOYSA-N InChI=1S/C19H15ClF2N4O4/c1-10(27)23-16-8-12(4-6-14(16)21)26-19(29)25(18(28)17(24-26)30-2)9-11-3-5-13(20)15(22)7-11/h3-8H,9H2,1-2H3,(H,23,27)
SMILES CC(=O)NC1=C(C=CC(=C1)N2C(=O)N(C(=O)C(=N2)OC)CC3=CC(=C(C=C3)Cl)F)F
Properties
Chemical formula	C19H15ClF2N4O4
Molar mass	436.80 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Therapeutic potential

Addiction

ADX-71441 has been shown to reduce alcohol consumption.^[1] This result was observed in both alcohol dependent and non-dependent animals.^[2][3]

There were also trials about nicotine addiction, which showed positive results: ADX-71441 was able to decrease some withdrawal symptoms of nicotine withdrawal.^[4]

Anxiety

This compound has also been shown to reduce anxiety in people with PTSD.^[5]

Pain

Experiments have shown that this compound was able to decrease hypersensitivity to pain in mice, Guinea pigs and rats.^[5]

Tolerance

ADX-71441 has been shown to have less tolerance and side effects than direct GABA_B agonists, such as baclofen.^[2]