ADX88178

ADX88178 is an experimental drug that acts as a positive allosteric modulator for the glutamate receptor mGluR4. It was developed as a potential medication for the treatment of Parkinson's disease but had mixed results in animal studies, improving dyskinesia but worsening psychosis-like symptoms. However it has antiinflammatory effects in brain tissue which may make it useful for other indications.^{[1][2][3][4][5][6]}

ADX88178

Identifiers
IUPAC name 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine
CAS Number	1235318-89-4
PubChem CID	46836872
IUPHAR/BPS	6238
ChemSpider	28294729
ChEMBL	ChEMBL3609729
Chemical and physical data
Formula	C12H12N6S
Molar mass	272.33 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=NC(=NC=C1)NC2=NC(=C(S2)C)C3=CNN=C3
InChI InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18) Key:MIQNXKWDQRNHAU-UHFFFAOYSA-N