Agmatinase

In enzymology, an agmatinase (EC 3.5.3.11) is an enzyme that catalyzes the chemical reaction

agmatine + H₂O ${\displaystyle \rightleftharpoons }$ putrescine + urea

agmatinase
agmatinase hexamer, Deinococcus radiodurans
Identifiers
EC no.	3.5.3.11
CAS no.	37289-16-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are agmatine and H₂O, whereas its two products are putrescine and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine amidinohydrolase. Other names in common use include agmatine ureohydrolase. This enzyme participates in urea cycle and metabolism of amino groups.

Genetics

AGMAT
Identifiers
Aliases	AGMAT, Agmatinase
External IDs	OMIM: 617887; MGI: 1923236; HomoloGene: 99855; GeneCards: AGMAT; OMA:AGMAT - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.21 Start 15,571,699 bp[1] End 15,585,051 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 141,473,983 bp[2] End 141,486,574 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus kidney tubule metanephric glomerulus renal medulla buccal mucosa cell human kidney jejunal mucosa liver vastus lateralis muscle mucosa of colon Top expressed in left lobe of liver epithelium of small intestine motor neuron duodenum Paneth cell fetal liver hematopoietic progenitor cell jejunum habenula migratory enteric neural crest cell morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines hydrolase activity metal ion binding agmatinase activity Cellular component mitochondrion Biological process putrescine biosynthetic process agmatine biosynthetic process spermidine biosynthetic process putrescine biosynthetic process from arginine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79814 75986 Ensembl ENSG00000116771 ENSMUSG00000040706 UniProt Q9BSE5 A2AS89 RefSeq (mRNA) NM_024758 NM_001081408 NM_001378862 RefSeq (protein) NP_079034 NP_001074877 NP_001365791 Location (UCSC) Chr 1: 15.57 – 15.59 Mb Chr 4: 141.47 – 141.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

In humans, the enzyme is encoded by the AGMAT gene.^[5][6][7][8]

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GQ6, 1GQ7, 1WOG, 1WOH, and 1WOI.

Inhibitors

• Piperazine-1-carboxamidine