AHNAK

Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a protein that in humans is encoded by the AHNAK gene.^[5][6][7] AHNAK was originally identified in 1989 (in bovine muzzle epidermal cells) and named desmoyokin due to its localization pattern (that resembled a yoke) in the desmosomal plaque.^[8] AHNAK has been shown to be essential for pseudopod protrusion and cell migration. ^[9]

AHNAK
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4DRW, 4FTG, 4HRG
Identifiers
Aliases	AHNAK, AHNAKRS, AHNAK nucleoprotein, PM227
External IDs	OMIM: 103390; MGI: 1316648; HomoloGene: 67425; GeneCards: AHNAK; OMA:AHNAK - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,433,542 bp[1] End 62,556,235 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 8,966,648 bp[2] End 9,054,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb Achilles tendon tendon of biceps brachii trigeminal ganglion saphenous vein mucosa of pharynx nipple epithelium of colon urethra skin of hip Top expressed in sciatic nerve ascending aorta corneal stroma aortic valve gastrula skin of external ear right lung lobe conjunctival fornix endothelial cell of lymphatic vessel tunica media of zone of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function S100 protein binding structural molecule activity conferring elasticity protein binding RNA binding cadherin binding Cellular component cytoplasm vesicle cytosol membrane cell-cell contact zone focal adhesion plasma membrane lysosomal membrane actin cytoskeleton membrane raft sarcolemma costamere extracellular exosome nucleus T-tubule Biological process regulation of voltage-gated calcium channel activity regulation of RNA splicing protein complex oligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79026 66395 Ensembl ENSG00000124942 ENSMUSG00000069833 UniProt Q09666 n/a RefSeq (mRNA) NM_001620 NM_024060 NM_001346445 NM_001346446 NM_001039959 NM_001286518 NM_009643 NM_175108 RefSeq (protein) NP_001333374 NP_001333375 NP_001611 NP_076965 n/a Location (UCSC) Chr 11: 62.43 – 62.56 Mb Chr 19: 8.97 – 9.05 Mb PubMed search [3] [4]
Wikidata
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Interactions

AHNAK has been shown to interact with S100B.^[10]