Allograft inflammatory factor 1-like

Allograft inflammatory factor 1-like is a protein that is encoded by the AIF1L gene in humans.^[5][6]

AIF1L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JJZ, 2VTG
Identifiers
Aliases	AIF1L, C9orf58, IBA2, allograft inflammatory factor 1 like
External IDs	MGI: 1919598; HomoloGene: 12863; GeneCards: AIF1L; OMA:AIF1L - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.12-q34.13 Start 131,096,476 bp[1] End 131,123,152 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 31,840,151 bp[2] End 31,863,454 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla C1 segment inferior ganglion of vagus nerve human kidney spleen internal globus pallidus ventral tegmental area medulla oblongata ventricular zone substantia nigra Top expressed in decidua stria vascularis cumulus cell ciliary body subiculum Region I of hippocampus proper retinal pigment epithelium maxillary prominence piriform cortex superior colliculus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding actin filament binding actin binding metal ion binding Cellular component cytoplasm actin cytoskeleton ruffle membrane plasma membrane cell projection extracellular exosome cytoskeleton membrane focal adhesion actin filament protein-containing complex Biological process actin filament bundle assembly ruffle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83543 108897 Ensembl ENSG00000126878 ENSMUSG00000001864 UniProt Q9BQI0 Q9EQX4 RefSeq (mRNA) NM_001002260 NM_001185095 NM_001185096 NM_031426 NM_145144 RefSeq (protein) NP_001172024 NP_001172025 NP_113614 NP_660126 Location (UCSC) Chr 9: 131.1 – 131.12 Mb Chr 2: 31.84 – 31.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AIF1L is an actin-binding protein that promotes actin bundling. It may neither bind calcium nor depend on calcium for function.^[7] It has biased expression in kidney (RPKM 130.1), spleen (RPKM 121.3) and 8 other tissues.^[8]