AH receptor-interacting protein

For the similarly named protein encoded by the AHR gene, see aryl hydrocarbon receptor.

AH receptor-interacting protein (AIP) also known as aryl hydrocarbon receptor-interacting protein, immunophilin homolog ARA9, or HBV X-associated protein 2 (XAP-2) is a protein that in humans is encoded by the AIP gene.^[5][6][7] The protein is a member of the FKBP family.

AIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LKN, 4AIF, 4APO
Identifiers
Aliases	AIP, ARA9, FKBP16, FKBP37, SMTPHN, XAP-2, XAP2, aryl hydrocarbon receptor interacting protein, PITA1
External IDs	OMIM: 605555; MGI: 109622; HomoloGene: 2959; GeneCards: AIP; OMA:AIP - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 67,468,174 bp[1] End 67,491,154 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 3.82 cM Start 4,164,446 bp[2] End 4,175,858 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte popliteal artery tibial arteries Descending thoracic aorta right coronary artery ascending aorta left coronary artery canal of the cervix body of uterus muscle layer of sigmoid colon Top expressed in neural layer of retina dentate gyrus of hippocampal formation granule cell granulocyte quadriceps femoris muscle yolk sac muscle tissue skeletal muscle tissue cerebellum hypothalamus olfactory bulb More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signal transducer activity transcription coregulator activity unfolded protein binding transcription factor binding GAF domain binding transcription coactivator activity aryl hydrocarbon receptor binding peptidyl-prolyl cis-trans isomerase activity Cellular component aryl hydrocarbon receptor complex membrane plasma membrane cytosol nucleoplasm cytoplasm Biological process protein targeting to mitochondrion negative regulation of cyclic-nucleotide phosphodiesterase activity regulation of protein kinase A signaling protein maturation by protein folding xenobiotic metabolic process interleukin-12-mediated signaling pathway regulation of nucleic acid-templated transcription positive regulation of nucleic acid-templated transcription protein peptidyl-prolyl isomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9049 11632 Ensembl ENSG00000110711 ENSMUSG00000024847 UniProt O00170 O08915 RefSeq (mRNA) NM_003977 NM_001302959 NM_001302960 NM_001276284 NM_016666 RefSeq (protein) NP_001289888 NP_001289889 NP_003968 NP_001263213 NP_057875 Location (UCSC) Chr 11: 67.47 – 67.49 Mb Chr 19: 4.16 – 4.18 Mb PubMed search [3] [4]
Wikidata
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Function

AIP may play a positive role in aryl hydrocarbon receptor-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. AIP is the cellular negative regulator of the hepatitis B virus (HBV) X protein.^[5] Further, it's been known to suppress antiviral signaling and the induction of type I interferon by targeting IRF7, a key player in the antiviral signal pathways.^[8] AIP consists of an N-terminal FKBP52 like domain and a C-terminal TPR domain.^[9]

Mutations and role in disease

AIP mutations may be the cause of a familial form of acromegaly, familial isolated pituitary adenoma (FIPA). Somatotropinomas (i.e. GH-producing pituitary adenomas), sometimes associated with prolactinomas, are present in most AIP mutated patients.^[10]

Interactions

AIP has been shown to interact with the aryl hydrocarbon receptor,^[7][11][12] peroxisome proliferator-activated receptor alpha^[13] and the aryl hydrocarbon receptor nuclear translocator.^[7][14] Further, it has shown that AIP can interact with IRF7 to exert its novel function of negatively regulating antiviral signal pathways.^[8]