AL-37350A

AL-37350A (4,5-DHP-AMT) is a tricyclic tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT_2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT_2B and 5-HT_2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treatment of glaucoma.^[1]

AL-37350A

Identifiers
IUPAC name (S)-(+)-1-(2-Aminopropyl)-8,9-dihydropyrano[3,2-e]indole
CAS Number	362603-40-5 Y
PubChem CID	10331436
IUPHAR/BPS	160
ChemSpider	8506896 Y
UNII	KT54N4CC67
ChEMBL	ChEMBL133455 Y
CompTox Dashboard (EPA)	DTXSID501350247 DTXSID10438239, DTXSID501350247
Chemical and physical data
Formula	C14H18N2O
Molar mass	230.311 g·mol−1
3D model (JSmol)	Interactive image
SMILES O2c1ccc3c(c1CCC2)c(c[nH]3)C[C@@H](N)C
InChI InChI=1S/C14H18N2O/c1-9(15)7-10-8-16-12-4-5-13-11(14(10)12)3-2-6-17-13/h4-5,8-9,16H,2-3,6-7,15H2,1H3/t9-/m0/s1 Y Key:VVHJUSGIUWQPIT-VIFPVBQESA-N Y
NY (what is this?)  (verify)

See also

• Ramelteon
• AL-38022A
• CP-132,484
• 4,5-DHP-DMT