ALDH1B1

Aldehyde dehydrogenase X, mitochondrial is an enzyme that in humans is encoded by the ALDH1B1 gene.^[5][6]

ALDH1B1
Identifiers
Aliases	ALDH1B1, ALDH5, ALDHX, aldehyde dehydrogenase 1 family member B1
External IDs	OMIM: 100670; MGI: 1919785; HomoloGene: 115470; GeneCards: ALDH1B1; OMA:ALDH1B1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.1 Start 38,392,702 bp[1] End 38,398,661 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 45,799,022 bp[2] End 45,804,604 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell right coronary artery tendon of biceps brachii popliteal artery tibial arteries thoracic aorta ascending aorta Descending thoracic aorta left coronary artery left uterine tube Top expressed in crypt of lieberkuhn of small intestine epithelium of small intestine migratory enteric neural crest cell ileum jejunum duodenum left colon atrium intestinal villus Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity aldehyde dehydrogenase (NAD+) activity NAD binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Cellular component mitochondrial matrix intracellular membrane-bounded organelle mitochondrion nucleoplasm Biological process ethanol catabolic process metabolism ethanol oxidation carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 219 72535 Ensembl ENSG00000137124 ENSMUSG00000035561 UniProt P30837 Q9CZS1 RefSeq (mRNA) NM_000692 NM_028270 RefSeq (protein) NP_000683 NP_082546 Location (UCSC) Chr 9: 38.39 – 38.4 Mb Chr 4: 45.8 – 45.8 Mb PubMed search [3] [4]
Wikidata
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Function

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems.^[6]