AMG-3

AMG-3 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ⁸-THC substituted with a dithiolane group on the 3-position side chain.^[1] AMG-3 is a potent agonist at both CB₁ and CB₂ receptors with a K_i of 0.32 nM at CB₁ and 0.52 nM at CB₂,^[2][3] and its particularly high binding affinity has led to it being used as a template for further structural development of novel cannabinoid drugs.^[4] It has sedative and analgesic effects, with analgesia lasting for up to 36 hours after administration.^[5]

AMG-3

Identifiers
IUPAC name (6aR,10aR)-3-(2-hexyl-1,3-dithiolan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
CAS Number	179044-94-1 N
PubChem CID	10002952
ChemSpider	8178532 N
UNII	U90K6D923K
ChEMBL	ChEMBL476325 N
CompTox Dashboard (EPA)	DTXSID701019037
Chemical and physical data
Formula	C25H36O2S2
Molar mass	432.68 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCCC4(SCCS4)c(cc1O)cc(OC(C)(C)C2CC=3)c1C2CC=3C
InChI InChI=1S/C25H36O2S2/c1-5-6-7-8-11-25(28-12-13-29-25)18-15-21(26)23-19-14-17(2)9-10-20(19)24(3,4)27-22(23)16-18/h9,15-16,19-20,26H,5-8,10-14H2,1-4H3/t19-,20-/m1/s1 N Key:JECXXFXYJAQVAH-WOJBJXKFSA-N N
NY (what is this?)  (verify)

See also

• AMG-36
• AMG-41