Angiopoietin-related protein 1

Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene.^[5][6][7]

ANGPTL1
Identifiers
Aliases	ANGPTL1, ANG3, ANGPT3, ARP1, AngY, UNQ162, dJ595C2.2, angiopoietin like 1
External IDs	OMIM: 603874; MGI: 1919963; HomoloGene: 128467; GeneCards: ANGPTL1; OMA:ANGPTL1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.2 Start 178,849,535 bp[1] End 178,871,077 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G3 Start 156,666,132 bp[2] End 156,688,648 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube smooth muscle tissue Achilles tendon tendon of biceps brachii popliteal artery tibial arteries muscle layer of sigmoid colon right ovary left coronary artery Descending thoracic aorta Top expressed in basilar part of occipital bone intercostal muscle squamous epithelium condyle mesothelium mesothelium of peritoneum rib human fetus sphenoid bone dermis More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding Cellular component extracellular exosome extracellular region extracellular space Biological process transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9068 72713 Ensembl ENSG00000116194 ENSMUSG00000033544 UniProt O95841 Q640P2 RefSeq (mRNA) NM_004673 NM_001376763 NM_028333 RefSeq (protein) NP_004664 NP_001363692 NP_082609 Location (UCSC) Chr 1: 178.85 – 178.87 Mb Chr 1: 156.67 – 156.69 Mb PubMed search [3] [4]
Wikidata
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Function

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels.

The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro.^[7]