Annexin A6

Annexin A6 is a protein that in humans is encoded by the ANXA6 gene.^[5]

ANXA6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M9I
Identifiers
Aliases	ANXA6, ANX6, CBP68, annexin A6, CPB-II, p70, p68
External IDs	OMIM: 114070; MGI: 88255; HomoloGene: 55558; GeneCards: ANXA6; OMA:ANXA6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 151,100,706 bp[1] End 151,157,785 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 32.13 cM Start 54,869,934 bp[2] End 54,924,271 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte smooth muscle tissue right coronary artery apex of heart stromal cell of endometrium popliteal artery muscle of thigh tibial arteries right ovary gastric mucosa Top expressed in internal carotid artery external carotid artery lactiferous gland yolk sac subcutaneous adipose tissue muscle of thigh facial motor nucleus dermis vestibular sensory epithelium stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein homodimerization activity GTP binding calcium-dependent protein binding cholesterol binding protein binding ligand-gated ion channel activity calcium-dependent phospholipid binding lipid binding phosphatidylserine binding calcium channel activity heparin binding enzyme binding chondroitin sulfate binding signaling receptor activity protein-containing complex binding actin filament binding Cellular component cytoplasm membrane late endosome membrane focal adhesion melanosome lysosomal membrane mitochondrion perinuclear region of cytoplasm extracellular exosome collagen-containing extracellular matrix Biological process regulation of muscle contraction mitochondrial calcium ion homeostasis ion transmembrane transport apoptotic signaling pathway protein homooligomerization calcium ion transport neural crest cell migration plasma membrane repair growth plate cartilage chondrocyte differentiation biomineral tissue development negative regulation of sequestering of calcium ion calcium ion import calcium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 309 11749 Ensembl ENSG00000197043 ENSMUSG00000018340 UniProt P08133 P14824 RefSeq (mRNA) NM_001155 NM_001193544 NM_004033 NM_001363114 NM_001110211 NM_013472 RefSeq (protein) NP_001146 NP_001180473 NP_001350043 NP_001103681 NP_038500 Location (UCSC) Chr 5: 151.1 – 151.16 Mb Chr 11: 54.87 – 54.92 Mb PubMed search [3] [4]
Wikidata
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Function

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Exon 21 of annexin VI is alternatively spliced, giving rise to two isoforms that differ by a 6-amino acid insertion at the start of the seventh repeat. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis.^[6]

Interactions

ANXA6 has been shown to interact with RAS p21 protein activator 1.^[7]