Apolipoprotein A-II

Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.^[5] It is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear. ^[6] Remarkably, defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.^[7]

APOA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L6L, 2OU1
Identifiers
Aliases	APOA2, Apo-AII, ApoA-II, apoAII, Apolipoprotein A2
External IDs	OMIM: 107670; MGI: 88050; HomoloGene: 1242; GeneCards: APOA2; OMA:APOA2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,222,292 bp[1] End 161,223,631 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.22 cM Start 171,052,623 bp[2] End 171,053,948 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver epithelium of colon testicle monocyte gonad bone marrow cells granulocyte left uterine tube tendon of biceps brachii blood Top expressed in left lobe of liver yolk sac fetal liver hematopoietic progenitor cell human fetus abdominal wall right kidney embryo blastocyst proximal tubule sexually immature organism More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipase inhibitor activity protein homodimerization activity phosphatidylcholine binding lipid transporter activity apolipoprotein receptor binding high-density lipoprotein particle receptor binding cholesterol binding protein binding protein heterodimerization activity phosphatidylcholine-sterol O-acyltransferase activator activity phospholipid binding cholesterol transfer activity lipid binding high-density lipoprotein particle binding heat shock protein binding signaling receptor binding Cellular component cytosol blood microparticle endoplasmic reticulum lumen chylomicron very-low-density lipoprotein particle spherical high-density lipoprotein particle extracellular region early endosome high-density lipoprotein particle extracellular exosome extracellular space Biological process negative regulation of cholesterol import negative regulation of very-low-density lipoprotein particle remodeling diacylglycerol catabolic process lipid transport regulation of protein stability positive regulation of cholesterol esterification phospholipid efflux cholesterol transport positive regulation of lipid catabolic process response to glucocorticoid negative regulation of cytokine production involved in immune response response to glucose high-density lipoprotein particle assembly retinoid metabolic process response to estrogen high-density lipoprotein particle remodeling negative regulation of lipase activity regulation of intestinal cholesterol absorption low-density lipoprotein particle remodeling acute inflammatory response animal organ regeneration phospholipid catabolic process peptidyl-methionine modification cholesterol efflux negative regulation of cholesterol transport cholesterol homeostasis phosphatidylcholine biosynthetic process negative regulation of cholesterol transporter activity viral process negative regulation of lipid catabolic process triglyceride-rich lipoprotein particle remodeling triglyceride metabolic process reverse cholesterol transport high-density lipoprotein particle clearance positive regulation of catalytic activity cholesterol metabolic process regulation of lipid metabolic process chylomicron remodeling chylomicron assembly lipoprotein metabolic process post-translational protein modification transport positive regulation of phagocytosis protein stabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 336 11807 Ensembl ENSG00000158874 ENSMUSG00000005681 UniProt P02652 P09813 RefSeq (mRNA) NM_001643 NM_013474 NM_001305549 NM_001305550 NM_001305585 RefSeq (protein) NP_001634 NP_001292478 NP_001292479 NP_001292514 NP_038502 Location (UCSC) Chr 1: 161.22 – 161.22 Mb Chr 1: 171.05 – 171.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ApoA-II
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
Identifiers
Symbol	ApoA-II
Pfam	PF04711
InterPro	IPR006801
SCOP2	1l6k / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Interactions

ApoA-II has been shown to interact with phospholipid transfer protein.^[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Statin pathway edit]]

Statin pathway edit

1. The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".