Aquaporin-5

Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene.^[5][6]

AQP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D9S, 5C5X, 5DYE
Identifiers
Aliases	AQP5, AQP-5, PPKB, aquaporin 5
External IDs	OMIM: 600442; MGI: 106215; HomoloGene: 20398; GeneCards: AQP5; OMA:AQP5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 49,961,872 bp[1] End 49,965,682 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 56.13 cM Start 99,488,663 bp[2] End 99,492,710 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa palpebral conjunctiva left testis right testis parotid gland skin of leg nasal epithelium minor salivary glands trachea skin of abdomen Top expressed in submandibular gland parotid gland lacrimal gland right lung right lung lobe respiratory epithelium olfactory epithelium trachea epithelium of lens left lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity protein binding water channel activity identical protein binding channel activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane microvillus basal plasma membrane apical plasma membrane endoplasmic reticulum extracellular exosome cytoplasmic vesicle membrane cytoplasmic vesicle Biological process excretion water transport pancreatic juice secretion saliva secretion odontogenesis ion transmembrane transport camera-type eye morphogenesis carbon dioxide transport transport transmembrane transport protein homotetramerization cellular hypotonic response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 362 11830 Ensembl ENSG00000161798 ENSMUSG00000044217 UniProt P55064 Q9WTY4 RefSeq (mRNA) NM_001651 NM_009701 RefSeq (protein) NP_001642 NP_033831 Location (UCSC) Chr 12: 49.96 – 49.97 Mb Chr 15: 99.49 – 99.49 Mb PubMed search [3] [4]
Wikidata
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Aquaporin-5 (AQP-5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 plays a role in the generation of saliva, tears and pulmonary secretions.^[6] AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.^[6]

AQP-5 features a homotetrameric structure embedded in the cell membrane with the center of each monomer acting as a water pore.^[7] Each monomer structure is a transmembrane protein which have an asparagine–proline–alanine (NPA) hydrophobic residue embedded in the membrane of the cell. The NPA residue plays a role in water and solute permeability across the membrane of the cell.^[7]