Aquaporin-9

Aquaporin-9 (AQP-9) is a protein that in humans is encoded by the AQP9 gene.^[5]

AQP9
Identifiers
Aliases	AQP9, AQP-9, HsT17287, SSC1, T17287, aquaporin 9
External IDs	OMIM: 602914; MGI: 1891066; HomoloGene: 41405; GeneCards: AQP9; OMA:AQP9 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.3 Start 58,138,169 bp[1] End 58,185,911 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 D Start 71,017,941 bp[2] End 71,075,964 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte right lobe of liver periodontal fiber granulocyte caput epididymis germinal epithelium corpus epididymis bone marrow right lung Top expressed in left lobe of liver spermatocyte granulocyte spermatid zygote secondary oocyte seminiferous tubule primary oocyte blood blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function porin activity carboxylic acid transmembrane transporter activity polyol transmembrane transporter activity water transmembrane transporter activity purine nucleobase transmembrane transporter activity pyrimidine nucleobase transmembrane transporter activity amine transmembrane transporter activity water channel activity urea channel activity glycerol channel activity channel activity urea transmembrane transporter activity Cellular component integral component of membrane intracellular membrane-bounded organelle membrane plasma membrane integral component of plasma membrane basolateral plasma membrane Biological process canalicular bile acid transport excretion water transport amine transport response to organic substance water homeostasis response to osmotic stress polyol transport carboxylic acid transport immune response pyrimidine nucleobase transport response to mercury ion glycerol transport cellular response to cAMP purine nucleobase transport carboxylic acid transmembrane transport purine nucleobase transmembrane transport pyrimidine-containing compound transmembrane transport transmembrane transport urea transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 366 64008 Ensembl ENSG00000103569 ENSMUSG00000032204 UniProt O43315 Q9JJJ3 RefSeq (mRNA) NM_020980 NM_001320635 NM_001320636 NM_001271843 NM_022026 RefSeq (protein) NP_001307564 NP_001307565 NP_066190 NP_001258772 NP_071309 Location (UCSC) Chr 15: 58.14 – 58.19 Mb Chr 9: 71.02 – 71.08 Mb PubMed search [3] [4]
Wikidata
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The aquaporins/major intrinsic protein are a family of water-selective membrane channels. Aquaporin-9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin-9 allows passage of a wide variety of noncharged solutes. AQP-9 stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. Aquaporin-9 may also have some role in specialized leukocyte functions such as immunological response and bactericidal activity.^[5]