AT-121

AT-121 is an experimental analgesic. It was designed to be bifunctional, acting as an agonist at both the μ-opioid receptor and the nociceptin receptor.^[1] The interaction with the nociceptin receptor is expected to block the abuse and dependence-related side effects that are typical of opioids.^[2] A study in nonhuman primates found that AT-121 has morphine-like analgesic effects, but suppressed the addictive effects.^[1][3]

AT-121

Legal status
Legal status	Investigational
Identifiers
IUPAC name 3-oxo-1'-(4-propan-2-ylcyclohexyl)-2-[2-(sulfamoylamino)ethyl]spiro[1H-isoquinoline-4,4'-piperidine]
CAS Number	2099681-31-7
PubChem CID	129188444
ChemSpider	114937398
Chemical and physical data
Formula	C24H38N4O3S
Molar mass	462.65 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)[C@H]1CC[C@H](CC1)N1CCC2(CC1)C(=O)N(CCNS(N)(=O)=O)CC1=CC=CC=C21
InChI InChI=1S/C24H38N4O3S/c1-18(2)19-7-9-21(10-8-19)27-14-11-24(12-15-27)22-6-4-3-5-20(22)17-28(23(24)29)16-13-26-32(25,30)31/h3-6,18-19,21,26H,7-17H2,1-2H3,(H2,25,30,31) Key:LIZMNXKYQXVRSS-UHFFFAOYSA-N

See also

• AT-076
• Cebranopadol
• Oliceridine
• PZM21