ATP5PF

ATP synthase-coupling factor 6, mitochondrial is an enzyme subunit that in humans is encoded by the ATP5PF gene.^[5][6][7]

ATP5PF
Identifiers
Aliases	ATP5PF, ATP5, ATP5A, ATPM, CF6, F6, ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6, ATP synthase peripheral stalk subunit F6, ATP5J
External IDs	OMIM: 603152; MGI: 107777; HomoloGene: 1272; GeneCards: ATP5PF; OMA:ATP5PF - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 25,716,503 bp[1] End 25,735,673 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 84,624,754 bp[2] End 84,632,513 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle right ventricle Epithelium of choroid plexus cardiac muscle tissue of right atrium biceps brachii Skeletal muscle tissue of rectus abdominis body of tongue vena cava Skeletal muscle tissue of biceps brachii vastus lateralis muscle Top expressed in right kidney digastric muscle saccule myocardium of ventricle thoracic diaphragm atrioventricular valve cardiac muscles facial motor nucleus triceps brachii muscle muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity proton transmembrane transporter activity transmembrane transporter activity ATPase activity protein-containing complex binding Cellular component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) proton-transporting ATP synthase complex, coupling factor F(o) membrane mitochondrial proton-transporting ATP synthase complex mitochondrial inner membrane mitochondrion extracellular space cell surface Biological process ATP synthesis coupled proton transport ion transport substantia nigra development ATP metabolic process mitochondrial ATP synthesis coupled proton transport ATP biosynthetic process cristae formation transport positive regulation of heart rate response to muscle activity negative regulation of prostaglandin secretion positive regulation of blood pressure negative regulation of arachidonic acid secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 522 11957 Ensembl ENSG00000154723 ENSMUSG00000022890 UniProt P18859 P97450 RefSeq (mRNA) NM_001003696 NM_001003697 NM_001003701 NM_001003703 NM_001685 NM_001320266 NM_001320267 NM_016755 NM_001302213 NM_001302214 NM_001302215 NM_001302216 NM_001358499 NM_001358500 RefSeq (protein) NP_001003696 NP_001003697 NP_001003701 NP_001003703 NP_001307195 NP_001307196 NP_001676 NP_001289142 NP_001289143 NP_001289144 NP_001289145 NP_058035 NP_001345428 NP_001345429 Location (UCSC) Chr 21: 25.72 – 25.74 Mb Chr 16: 84.62 – 84.63 Mb PubMed search [3] [4]
Wikidata
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Mitochondrial ATP synthase coupling factor 6 (F6)
solution structure of subunit f6 from the peripheral stalk region of atp synthase from bovine heart mitochondria
Identifiers
Symbol	ATP-synt_F6
Pfam	PF05511
InterPro	IPR008387
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Function

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F₁, and the membrane-spanning component, F_O, which comprises the proton channel. The F₁ complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F_O seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the F_O complex, required for F₁ and F_O interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.^[7]

The F6 subunit is part of the peripheral stalk that links the F₁ and F_O complexes together, and which acts as a stator to prevent certain subunits from rotating with the central rotary element. The peripheral stalk differs in subunit composition between mitochondrial, chloroplast and bacterial F-ATPases. In mitochondria, the peripheral stalk is composed of one copy each of subunits OSCP (oligomycin sensitivity conferral protein), F6, b and d.^[8] There is no homologue of subunit F6 in bacterial or chloroplast F-ATPase, whose peripheral stalks are composed of one copy of the delta subunit (homologous to OSCP), and two copies of subunit b in bacteria, or one copy each of subunits b and b' in chloroplasts and photosynthetic bacteria.