Renin receptor

The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.^[5][6][7]

ATP6AP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LBS, 3LC8
Identifiers
Aliases	ATP6AP2, APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028, ATPase H+ transporting accessory protein 2, CDG2R
External IDs	OMIM: 300556; MGI: 1917745; HomoloGene: 38097; GeneCards: ATP6AP2; OMA:ATP6AP2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.4 Start 40,579,372 bp[1] End 40,606,848 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A1.1 Start 12,454,040 bp[2] End 12,483,288 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura tibia germinal epithelium parietal pleura epithelium of nasopharynx retinal pigment epithelium mucosa of paranasal sinus orbitofrontal cortex lateral nuclear group of thalamus renal medulla Top expressed in Epithelium of choroid plexus Paneth cell ciliary body iris retinal pigment epithelium conjunctival fornix substantia nigra medial dorsal nucleus medial geniculate nucleus aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding enzyme binding signaling receptor activity Cellular component integral component of membrane plasma membrane extracellular exosome membrane external side of plasma membrane neuron projection cell body tertiary granule membrane ficolin-1-rich granule membrane extracellular space apical plasma membrane Biological process positive regulation of transforming growth factor beta1 production rostrocaudal neural tube patterning head morphogenesis regulation of MAPK cascade eye pigmentation angiotensin maturation positive regulation of Wnt signaling pathway neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10159 70495 Ensembl ENSG00000182220 ENSMUSG00000031007 UniProt O75787 Q9CYN9 RefSeq (mRNA) NM_005765 NM_027439 RefSeq (protein) NP_005756 NP_081715 Location (UCSC) Chr X: 40.58 – 40.61 Mb Chr X: 12.45 – 12.48 Mb PubMed search [3] [4]
Wikidata
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Function

The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.^[8]

This protein is associated with proton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.^[7]