Attractin

For the ATRN Extended SMTP command, see On-Demand Mail Relay.

Attractin is a protein that in humans is encoded by the ATRN gene.^[5][6][7]

ATRN
Identifiers
Aliases	ATRN, DPPT-L, MGCA, attractin
External IDs	OMIM: 603130; MGI: 1341628; HomoloGene: 22542; GeneCards: ATRN; OMA:ATRN - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 3,471,018 bp[1] End 3,651,118 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.26 cM Start 130,748,415 bp[2] End 130,872,253 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum lateral nuclear group of thalamus stromal cell of endometrium orbitofrontal cortex jejunal mucosa subthalamic nucleus islet of Langerhans superior vestibular nucleus external globus pallidus Pons Top expressed in transitional epithelium of urinary bladder primary motor cortex subdivision of hippocampus Region I of hippocampus proper piriform cortex dentate gyrus olfactory tubercle globus pallidus dentate gyrus of hippocampal formation granule cell cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding signaling receptor activity Cellular component cytoplasm integral component of membrane extracellular region plasma membrane integral component of plasma membrane extracellular exosome membrane extracellular space Biological process myelination pigmentation inflammatory response response to oxidative stress cerebellum development regulation of multicellular organism growth animal organ morphogenesis tissue development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8455 11990 Ensembl ENSG00000088812 ENSMUSG00000027312 UniProt O75882 Q9WU60 RefSeq (mRNA) NM_001207047 NM_012070 NM_139321 NM_139322 NM_001323332 NM_009730 RefSeq (protein) NP_001193976 NP_001310261 NP_647537 NP_647538 NP_033860 Location (UCSC) Chr 20: 3.47 – 3.65 Mb Chr 2: 130.75 – 130.87 Mb PubMed search [3] [4]
Wikidata
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Attractin is a Group XI C-type lectin.

Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.^[7]