Acireductone synthase

Acireductone synthase (EC number 3.1.3.77, E1, E-1 enolase-phosphatase) is an enzyme with systematic name 5-(methylsulfanyl)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing).^[1][2][3] It catalyses the following reaction:

5-(methylsulfanyl)-2,3-dioxopentyl phosphate + H₂O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate (overall reaction)

(1a) 5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate (probably spontaneous)

(1b) 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate + H₂O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate

Acireductone synthase
Identifiers
EC no.	3.1.3.77
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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