Adenosylcobinamide-phosphate synthase

Adenosylcobinamide-phosphate synthase (EC 6.3.1.10, CbiB) is an enzyme with systematic name adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming).^[1][2] This enzyme catalyses the following chemical reaction

(1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate ${\displaystyle \rightleftharpoons }$ ADP + phosphate + adenosylcobinamide phosphate

(2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol ${\displaystyle \rightleftharpoons }$ ADP + phosphate + adenosylcobinamide

Adenosylcobinamide-phosphate synthase
Identifiers
EC no.	6.3.1.10
CAS no.	905988-16-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

One of the substrates, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (EC 4.1.1.81). This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in bacteria.

See also

• Cobalamin biosynthesis