Adenovirus vaccine

This article is about vaccination against adenoviruses. For adenoviruses as vaccine vectors, see Viral vector vaccine § Adenovirus.

An adenovirus vaccine is a vaccine against adenovirus infection.^[3] According to the American CDC, "There is currently no adenovirus vaccine available to the general public.^[4]

Adenovirus vaccine

Bottles of the vaccine
Vaccine description
Target	Adenovirus
Vaccine type	Live virus
Clinical data
AHFS/Drugs.com	Monograph
License data	US DailyMed: Adenovirus type
Routes of administration	Oral administration
ATC code	None
Legal status
Legal status	US: ℞-only[1][2]
Identifiers
DrugBank	DB14409
UNII	FKD3DUK39I TM54L796SN

It should not be confused with the strategy of using adenovirus as a viral vector to develop vaccines for other pathogens, or as a general gene carrier.^[5][6][7]

US military

It was used by the United States military from 1971 to 1999, but was discontinued when the only manufacturer stopped production.^[8][9] This vaccine elicited immunity to adenovirus serotypes 4 and 7,^[10] the serotypes most often associated with acute respiratory disease. On 16 March 2011, the U.S. Food and Drug Administration approved an adenovirus vaccine manufactured by Teva Pharmaceuticals under contract to the U.S. Army.^[11] This vaccine is essentially the same as the one used from 1971 to 1999. On 24 October 2011, the military services began administering the new adenovirus vaccine to recruits during basic training.^[12]

The vaccine is orally administered and consists of live (not attenuated) virus. The tablets are coated, so that the virus passes the stomach and infects the intestines, where the immune response is raised.^[13]