Aldose-6-phosphate reductase (NADPH)

In enzymology, an aldose-6-phosphate reductase (NADPH) (EC 1.1.1.200) is an enzyme that catalyzes the chemical reaction

D-sorbitol 6-phosphate + NADP⁺ ${\displaystyle \rightleftharpoons }$ D-glucose 6-phosphate + NADPH + H⁺

aldose-6-phosphate reductase (NADPH)
Identifiers
EC no.	1.1.1.200
CAS no.	76901-04-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NADP⁺, whereas its 3 products are D-glucose 6-phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-aldose-6-phosphate:NADP⁺ 1-oxidoreductase. Other names in common use include aldose 6-phosphate reductase, NADP⁺-dependent aldose 6-phosphate reductase, A6PR, aldose-6-P reductase, aldose-6-phosphate reductase, alditol 6-phosphate:NADP⁺ 1-oxidoreductase, and aldose-6-phosphate reductase (NADPH).