Alovudine

Alovudine (fluorothymidine) is an antiviral agent which was being developed by Medivir. It was discontinued after a Phase II trial in 2005 due to toxicity. It is a DNA polymerase inhibitor.^[1]

Alovudine

Clinical data
Other names	Fluorothymidine
ATC code	none
Identifiers
CAS Number	25526-93-6 N
PubChem CID	33039
ChemSpider	30578 Y
UNII	PG53R0DWDQ
KEGG	D02830 Y
ChEMBL	ChEMBL105318 Y
CompTox Dashboard (EPA)	DTXSID4046579
Chemical and physical data
Formula	C10H13FN2O4
Molar mass	244.222 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C/1NC(=O)N(\C=C\1C)[C@@H]2O[C@@H]([C@@H](F)C2)CO
InChI InChI=1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1 Y Key:UXCAQJAQSWSNPQ-XLPZGREQSA-N Y
NY (what is this?)  (verify)

See also

• Fluorothymidine F-18, an isotopically enriched version of alovudine used as a PET tracer