Alpha-1-microglobulin/bikunin precursor

Protein AMBP is a protein that in humans is encoded by the AMBP gene.^[5][6][7]

AMBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BIK, 3QKG, 4ES7, 4U30
Identifiers
Aliases	AMBP, A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI, alpha-1-microglobulin/bikunin precursor
External IDs	OMIM: 176870; MGI: 88002; HomoloGene: 1234; GeneCards: AMBP; OMA:AMBP - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q32 Start 114,060,127 bp[1] End 114,078,328 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B3|4 33.96 cM Start 63,061,512 bp[2] End 63,073,036 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver gallbladder body of pancreas islet of Langerhans testicle oocyte pancreatic epithelial cell secondary oocyte human kidney gonad Top expressed in left lobe of liver gallbladder fetal liver hematopoietic progenitor cell yolk sac human fetus abdominal wall right lobe of liver islet of Langerhans embryo sexually immature organism More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity calcium channel inhibitor activity protein homodimerization activity calcium oxalate binding protein binding heme binding serine-type endopeptidase inhibitor activity small molecule binding IgA binding Cellular component blood microparticle intracellular membrane-bounded organelle plasma membrane extracellular region cell surface extracellular exosome extracellular space extracellular matrix collagen-containing extracellular matrix Biological process negative regulation of peptidase activity female pregnancy receptor-mediated endocytosis negative regulation of JNK cascade heme catabolic process negative regulation of immune response cell adhesion protein catabolic process viral process negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 259 11699 Ensembl ENSG00000106927 ENSMUSG00000028356 UniProt P02760 Q07456 RefSeq (mRNA) NM_001633 NM_007443 RefSeq (protein) NP_001624 NP_031469 Location (UCSC) Chr 9: 114.06 – 114.08 Mb Chr 4: 63.06 – 63.07 Mb PubMed search [3] [4]
Wikidata
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Interactions

Alpha-1-microglobulin/bikunin precursor has been shown to interact with CD79A.^[8][9]

See also

• Inter-alpha-trypsin inhibitor
• Alpha-1-microglobulin