Alpha-bisabolene synthase

α-Bisabolene synthase (EC 4.2.3.38, bisabolene synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((E)-α-bisabolene-forming).^[1]

α-isabolene synthase
Identifiers
EC no.	4.2.3.38
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme catalyses the following chemical reaction:

(2E,6E)-farnesyl diphosphate ${\displaystyle \rightleftharpoons }$ (E)-α-bisabolene + diphosphate

This synthase requires a divalent cation cofactor (Mg²⁺ or, to a lesser extent, Mn²⁺) to neutralize the negative charge of the diphosphate leaving group.