Α-Mannosidase

α-Mannosidase (EC 3.2.1.24, α-D-mannosidase, p-nitrophenyl-α-mannosidase, α-D-mannopyranosidase, 1,2-α-mannosidase, 1,2-α-D-mannosidase, exo-α-mannosidase) is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase.^[3][4]

Cartoon depiction of the protein Streptococcus pyogenes family GH38 α-Mannosidase created using PyMol.^[1][2]

α-Mannosidase
α-Mannosidase 1, tetramer, Saccharomyces cerevisiae
Identifiers
EC no.	3.2.1.24
CAS no.	9025-42-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Isoenzymes

Humans express the following three α-mannosidase isoenzymes:

mannosidase, α, class 2B, member 1 Identifiers Symbol MAN2B1 Alt. symbols MANB NCBI gene 4125 HGNC 6826 OMIM 609458 RefSeq NM_000528 UniProt O00754 Other data EC number 3.2.1.24 Locus Chr. 19 cen-q13.1 Search for Structures Swiss-model Domains InterPro

mannosidase, α, class 2B, member 2 Identifiers Symbol MAN2B2 Alt. symbols KIAA0935 NCBI gene 23324 HGNC 29623 RefSeq NM_015274 UniProt Q9Y2E5 Other data EC number 3.2.1.24 Locus Chr. 4 p16.2 Search for Structures Swiss-model Domains InterPro

mannosidase, α, class 2C, member 1 Identifiers Symbol MAN2C1 Alt. symbols MANA1, MANA NCBI gene 4123 HGNC 6827 OMIM 154580 RefSeq NM_006715 UniProt Q9NTJ4 Other data EC number 3.2.1.24 Locus Chr. 15 q11-qter Search for Structures Swiss-model Domains InterPro

Applications

It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.^[5]

Pathology

A deficiency can lead to α-mannosidosis.^[6]