Glycoprotein hormones, alpha polypeptide

Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene.^[5]

CGA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DZ7, 1E9J, 1FL7, 1HCN, 1HD4, 1HRP, 1QFW, 1XWD, 4AY9, 4MQW
Identifiers
Aliases	CGA, CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA, Chorionic gonadotropin alpha, glycoprotein hormones, alpha polypeptide, Alpha subunit of glycoprotein hormones, GPA1
External IDs	OMIM: 118850; MGI: 88390; HomoloGene: 587; GeneCards: CGA; OMA:CGA - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.3 Start 87,085,498 bp[1] End 87,095,106 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 16.86 cM Start 34,893,779 bp[2] End 34,907,370 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary placenta buccal mucosa cell testicle tail of epididymis gonad amniotic fluid decidua islet of Langerhans hair follicle Top expressed in pituitary gland median eminence anterior pituitary pars tuberalis arcuate nucleus pars distalis of adenohypophysis morula embryo outer nuclear layer blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding hormone activity follicle-stimulating hormone activity Cellular component Golgi lumen extracellular region extracellular space follicle-stimulating hormone complex Biological process cell-cell signaling peptide hormone processing positive regulation of cell population proliferation positive regulation of transcription by RNA polymerase II signal transduction positive regulation of cell migration regulation of transcription by RNA polymerase II regulation of signaling receptor activity G protein-coupled receptor signaling pathway positive regulation of steroid biosynthetic process thyroid hormone generation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1081 12640 Ensembl ENSG00000135346 ENSMUSG00000028298 UniProt P01215 P01216 RefSeq (mRNA) NM_001252383 NM_000735 NM_009889 RefSeq (protein) NP_000726 NP_001239312 NP_034019 Location (UCSC) Chr 6: 87.09 – 87.1 Mb Chr 4: 34.89 – 34.91 Mb PubMed search [3] [4]
Wikidata
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Thyroid-stimulating hormone (TSH) and the gonadotropin hormones human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently. The alpha subunits of these four human glycoprotein hormones are identical; however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.^[6] CGA levels are regulated by ELAVL1/HuR, and the small molecule Eltrombopag, which targets HuR/RNA interactions, has been shown to reduce CGA levels in human cultured cells.^[7]