Alternative ribosome-rescue factor B

Alternative ribosome-rescue factor B (ArfB, YaeJ) also known as peptidyl-tRNA hydrolase,^[1] is a protein that plays a role in rescuing of stalled ribosomes.^[1] It works like a GGQ-release factor itself, releasing the peptide from tRNA.^[2] At the same time, it fits into the mRNA tunnel to remove the mRNA.^[3]

Peptidyl-tRNA hydrolase ArfB
Identifiers
Organism	E. coli
Symbol	ArfB
UniProt	P40711
Search for Structures Swiss-model Domains InterPro

This gene is also found in eukaryotic organelles as MRPL58 (ICT1). The similarity is high enough to be interchangeable.^[4] Its role has expanded to that of a codon-independent release factor, although it likely still functions in ribosomal rescue.^[5]

See also

• ArfA - Alternative ribosome-rescue factor A