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Amentoflavone

Chemical compound From Wikipedia, the free encyclopedia

Amentoflavone
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Amentoflavone is a biflavonoid (bis-apigenin coupled at 8 and 3 positions, or 3,8-biapigenin) constituent of a number of plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Biophytum sensitivum, Selaginella tamariscina,[1] Hypericum perforatum (St. John's Wort)[2] and Xerophyta plicata.[3]

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Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body.[4] It is also an inhibitor of human cathepsin B.[2]

Amentoflavone has a variety of in vitro activities including antimalarial activity,[5] anticancer activity (which may, at least in part, be mediated by its inhibition of fatty acid synthase),[6][7][8] and antagonist activity at the κ-opioid receptor (Ke = 490 nmol L1)[9] as well as activity at the allosteric benzodiazepine site of the GABAA receptor as a negative allosteric modulator.[10]

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