Aminosteroid

Aminosteroids are a group of steroids with a similar structure based on an amino-substituted steroid nucleus.^[1][2] They are neuromuscular blocking agents, acting as competitive antagonists of the nicotinic acetylcholine receptor (nAChR), and block the signaling of acetylcholine in the nervous system.^[1][2][3] These drugs include candocuronium iodide (chandonium iodide), dacuronium bromide, dihydrochandonium, dipyrandium, malouetine, pancuronium bromide, pipecuronium bromide, rapacuronium bromide, rocuronium bromide, stercuronium iodide, and vecuronium bromide.^[2][4]

Pancuronium, the first aminosteroid neuromuscular blocking agent to be introduced.

See also

• Benzylisoquinolines, such as atracurium and tubocurarine, the other major group of neuromuscular blocking agents