Amiphenazole

Amiphenazole (Daptazile) is a respiratory stimulant traditionally used as an antidote for barbiturate or opiate overdose, usually in combination with bemegride,^[1][2] as well as poisoning from other sedative drugs^[3][4] and treatment of respiratory failure from other causes.^[5] It was considered particularly useful as it could counteract the sedation and respiratory depression produced by morphine but with less effect on analgesia.^[6][7] It is still rarely used in medicine in some countries, although it has largely been replaced by more effective respiratory stimulants such as doxapram and specific opioid antagonists such as naloxone.^[8][9]

Amiphenazole

Clinical data
ATC code	none
Legal status
Legal status	AU: S4 (Prescription only)
Identifiers
IUPAC name 5-phenyl-1,3-thiazole-2,4-diamine
CAS Number	490-55-1
PubChem CID	10275
ChemSpider	9855 Y
UNII	7ZJ8PWY0XD
ChEMBL	ChEMBL1514085
CompTox Dashboard (EPA)	DTXSID7046388
ECHA InfoCard	100.007.013
Chemical and physical data
Formula	C9H9N3S
Molar mass	191.25 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)C2=C(N=C(S2)N)N
InChI InChI=1S/C9H9N3S/c10-8-7(13-9(11)12-8)6-4-2-1-3-5-6/h1-5H,10H2,(H2,11,12) Y Key:UPOYFZYFGWBUKL-UHFFFAOYSA-N Y
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