Amperozide

Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT_2A receptor.^[1] It does not block dopamine receptors as with most antipsychotic drugs,^[2] but does inhibit dopamine release,^[3][4] and alters the firing pattern of dopaminergic neurons.^[5] It was investigated for the treatment of schizophrenia in humans,^[6] but never adopted clinically. Its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity.^[7][8][9]

Amperozide

Clinical data
ATCvet code	QN05AX90 (WHO)
Identifiers
IUPAC name 4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide
CAS Number	75558-90-6 Y
PubChem CID	73333
ChemSpider	66062 Y
UNII	0M2W3TAG39
ChEMBL	ChEMBL1079935 Y
CompTox Dashboard (EPA)	DTXSID6048416
Chemical and physical data
Formula	C23H29F2N3O
Molar mass	401.502 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCNC(=O)N1CCN(CC1)CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F
InChI InChI=1S/C23H29F2N3O/c1-2-26-23(29)28-16-14-27(15-17-28)13-3-4-22(18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19/h5-12,22H,2-4,13-17H2,1H3,(H,26,29) Y Key:NNAIYOXJNVGUOM-UHFFFAOYSA-N Y
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See also

• FG-5893