Anicequol

Anicequol
Clinical data
Other names	NGA0187; NGD-187; 16β-Acetoxy-3β,7β,11β-trihydroxy-5α-ergost-22E-en-6-one
Identifiers
	IUPAC name [(3S,5S,7R,8S,9S,10R,11S,13S,14S,16S,17R)-17-[(E,2R,5R)-5,6-Dimethylhept-3-en-2-yl]-3,7,11-trihydroxy-10,13-dimethyl-6-oxo-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-16-yl] acetate;
CAS Number	163565-48-8;
PubChem CID	10413810;
ChemSpider	8589244;
UNII	5HJL84XH3J;
ChEMBL	ChEMBL1770668;
CompTox Dashboard (EPA)	DTXSID201045471 ;
Chemical and physical data
Formula	C30H48O6
Molar mass	504.708 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1[C@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2[C@H](C(=O)[C@@H]4[C@@]3(CC[C@@H](C4)O)C)O)O)C)OC(=O)C;
	InChI InChI=1S/C30H48O6/c1-15(2)16(3)8-9-17(4)25-23(36-18(5)31)13-20-24-26(22(33)14-30(20,25)7)29(6)11-10-19(32)12-21(29)27(34)28(24)35/h8-9,15-17,19-26,28,32-33,35H,10-14H2,1-7H3/b9-8+/t16-,17+,19-,20-,21+,22-,23-,24-,25-,26-,28+,29-,30-/m0/s1; Key:LWMKDRSIMLTGDK-TZEVRYHJSA-N;

Anicequol (developmental code names NGA0187, NGD-187)^[1] is a naturally occurring ergostane steroid produced by Acremonium sp. TF-0356 which has nerve growth factor-like neurotrophic activity.^[2]^[3]^[4] It was under investigation by Taisho Pharmaceutical in Japan for the treatment of cognitive disorders in the 1990s, but development was discontinued and the drug was never marketed.^[5]

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Chemistry