Antazoline

Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.^[1] To treat allergic conjunctivitis, antazoline can be combined in a solution with tetryzoline.^[2] The drug is a Histamine H1 receptor antagonist:^[3] selectively binding to but not activating the receptor, thereby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.

Antazoline

Clinical data
Trade names	Vasocon-a
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Topical (nasal, eye drops)
ATC code	R01AC04 (WHO) R06AX05 (WHO)
Identifiers
IUPAC name N-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline
CAS Number	91-75-8 Y
PubChem CID	2200
IUPHAR/BPS	7116
DrugBank	DB08799 Y
ChemSpider	2115 Y
UNII	DHA8014SS1
KEGG	D07458 Y
ChEBI	CHEBI:84115 N
ChEMBL	ChEMBL1305 Y
CompTox Dashboard (EPA)	DTXSID3022613
ECHA InfoCard	100.001.904
Chemical and physical data
Formula	C17H19N3
Molar mass	265.360 g·mol−1
3D model (JSmol)	Interactive image
SMILES N\1=C(\NCC/1)CN(c2ccccc2)Cc3ccccc3
InChI InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19) Y Key:REYFJDPCWQRWAA-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

A large study on people 65 years old or older linked the development of Alzheimer's disease and other forms of dementia to the "higher cumulative" use of first-generation antihistamines, due to their anticholinergic properties.^[4]