Antisialagogue

Antisialagogues are drugs or substances that decrease the flow rate of saliva and their effect is opposite to that of sialagogues.^[1] Their origin may be both natural and synthetic.

Anticholinergics generally have antisialagogue effects, and most produce some level of sedation, both being advantageous in surgical procedures.^[2]

Classic antisialagogues^[1] include:

• atropine,
• opioids,
• alkalis,
• hyoscyamine,
• scopolamine,
• tobacco in excess,
• most cannabinoids,^[3]
• all nauseous or insipid substances.